Grifols Engineering Solutions

Grifols Engineering, which  earned its internationally renowned reputation after years of hands-on experience developing Grifols’ industry-leading manufacturing capabilities  now provides the same service excellence to others in the biopharmaceutical sector.

• Modular designs reduce the time to validation and start-up
• Flexible designs that adapt to existing facilities
• Automated processes with efficient and practical plans

We offer two project management models:

• Integral turnkey project management for the biotech industry or sterile liquid manufacturing
• Project management in stages:
  • Conceptual design
  • Basic engineering
  • Detailed engineering
  • Implementation and startup

Our experience in our plasma derivatives manufacturing plants enables us to work on both upstream and downstream processes.

UPSTREAM

• Fermenters
• Media and buffer tanks
• Harvest tanks

These systems can be fully automated, minimizing running costs. The systems incorporate automated cleaning and sterilization processes, which can be validated.

DOWNSTREAM

• Tangential filtration units:
  • Fully automated systems
  • Integrated system cleaning process
  • Configured to client requirements
  • Monitoring and recording of system control parameters

• Chromatography columns:
  • Fully automated systems
  • Automatic elimination of air bubbles
  • Configured to client needs
  • Detects chromatography peaks

• Viral inactivation:
  • Thermal
  • Chemical
  • Filtration

• Machines for aseptic dosing of liquids GSF^® (Grifols Sterile Filling):
  • Unique patented system for dosing liquid products under aseptic conditions
  • Global solutions: preparation and sterilization of components, handling, aseptic filling, process control and laser etching
  • More than 20 years of reliable aseptic dosing

We specialize in the design of general processes for the pharmaceutical industry:

• IV solutions:
  • Installation design and construction
  • Comprehensive turnkey project management
  • Technical support and documentation for the facility and product approval procedures
  • Re-engineering and automation of pending processes

• Clean in place (CIP) and sterilization in place (SIP) units:
  • Innovative designs: with single tank and a single pump
  • Combined CIP: reactor and production line cleaning
  • Configured for any needs
  • Programmable logic controllers (PLCs) and touchscreen controls
  • Conforms to ASME-BPE 2002

• Modular Cleanrooms: Misterium^® (Mini Sterile Room)
  • Configurable modular cleanroom system
  • Multiple applications in the biopharmaceutical industry: processes requiring isolated, controlled and easy-to-clean environments, in-process microbial controls, pilot plants etc. 

• Pharmaceutical Quality Water:
  • Systems to produce water for injection (WFI), purified water (PW) and highly purified water (HPW)
  • Compatible with water from wells or water systems
  • Water distribution loops at 4ºC, ambient temperature or 80ºC
  • In-house design of SCADA for system control
  • Innovative, easy-to-clean, U.S. FDA -approved designs