Biopharma Manufacturing Technology

Totally automated production lines for filling diagnostic reagents cards.

• Increased yield
• Increased filling quality
• Can be adapted to different formats

Fully automated lines for the assembly of caps.

• Automated 3-piece cap assembly machine
• 3,000 pieces/hour. PLC-controlled and touchscreen operated

Grifols Engineering plasma bag opener (PBO) is designed to perform the following tasks: 

• The frozen plasma inside the bag is skin-thawed to create a liquid film inside the bag
• The outer surface of the bag is then rinsed with fresh deionized (DI) water or water for injection (WFI), removing any particles adhered to it
• The outer surface of the bag is then dried to start the manufacturing process
• A robotic system cuts the plasma bag and the plasma is removed from the bag and transferred to the processing tank
   

The Automatic Bottle Opener (ABO) is a thawing tunnel and plasma bottle washing and cutting and handling line designed by Grifols Engineering to perform series of sequential tasks: 

• The frozen plasma inside the bottle is skin-thawed to create a liquid film inside the bottle
• The outer surface of the plastic bottle is rinsed with fresh deionized (DI) water or water for injection (WFI), removing any particles adhered to it
• The outer surface is dried with air jets
• The bottle is automatically cut, the plasma is separated from the bottle and the product is transferred to the processing tank
   

Plasma Bottle and Bag Sampling (PBS) is a patented system designed and manufactured by Grifols Engineering. It provides added accuracy and safety during manipulation of plasma samples.

The Plasma Cutting Machine (PCM) is a patented system designed and manufactured by Grifols Engineering. It provides a high level of safety as the plasma is not handled by the operator while the bottles and bags are cut, minimizing possible external contamination, reducing costs and increasing yield.

Grifols Sterile Filling Systems provide a different approach to conventional aseptic filling. G.S.F^® minimizes the potential risk of airborne particle contamination during filling, ensuring the maximum quality of the product.

• Unique patented process for filling liquid products in sterile conditions
• Global solution: preparation and sterilization system of components, handling, sterile filling, process control and vial laser etching
• More than 15 years of proven reliability in sterile filling

Main Advantages:

• Vial is closed and protected throughout the process
• Vial is opened in the final filling stage in a controlled environment with horizontal laminar flow
• Sterilization and depyrogenation combined with HWFI is a washing cycle followed by autoclave cycle, eliminating the need for a dry heat tunnel

Automatic production line for aseptic liquid with secondary filling, stoppering, sealing and laser etching.

Automated and semi-automated sterile filling machines for filling and capping flexible bags with pharmaceutical solutions, in compliance with the strict requirements of Good Manufacturing Practices (GMP).

Creative and tailor-made solutions for the biotech and parenteral nutrition market.